High-Speed Atomic Force Microscopy allowed the characterization of the entire landscape of structural shapes that the amino acid transporter could adopt (yellow-red area with population density lines) between its open (A,B,C) and closed (D,E) states. The molecules in one corner of the conformational landscape (top right, red) were found to be trapped in an inactive state. Credit: Scheuring lab.
Researchers at Weill Cornell Medicine have developed a powerful, new technique to...
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